dCas9 Synergistic Activation Mediator Lentivirus

Cat. No.
4 x 500ul
Cat. No. K016
Name dCas9 Synergistic Activation Mediator Lentivirus
Unit 4 x 500ul

This Cas9 Double Mutant (dCas9) has changes at amino acid positions D10A and H840A which completely inactivate both the nuclease and nickase activities. With a target-specific guide RNA (sgRNA), it can bind to a specific region of DNA without cutting it. In this construct, dCas9 carries a C-terminal tripartite synergistic activation mediator (SAM). By targeting dCas9-SAM to a promoter region, users will be able to specifically induce expression of virtually any gene of interest.

Vector pLenti-EF1a-dCas9-SAM
Titer 107 IU/mL
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