dCas9-TET1CD Lentivirus

Cat. No.
4 x 500ul
Cat. No. K090
Name dCas9-TET1CD Lentivirus
Unit 4 x 500ul

This construct consists of the catalytic domain of Ten-Eleven Translocation dioxygenase 1 (TET1CD) fused to the C-terminus of Cas9 Double Mutant (dCas9). The Cas9 Double Mutant has changes at amino acid positions D10A and H840A which completely inactivate both nuclease and nickase activities; whereas the TET1 domain facilitates the process of demethylation leading to transcriptional up-regulation. By using specific sgRNAs, the dCas9-TET1CD can be targeted to a promoter region allowing for epigenetic control over the expression of almost any gene of interest.

Vector pLenti-EF1a-dCas9-tet1CD
Titer 107 IU/mL
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