Anti-ABCB1 Antibody
Cat. No.
Y052106
Unit
100 μg
Price
$839.00
| Cat. No. | Y052106 |
| Name | Anti-ABCB1 Antibody |
| Clone | Polyclonal |
| Category | Polyclonal Antibodies |
| Gene Name | ABCB1 |
| Alias | P-gp, CD243, GP170, ABC20 |
| Application | WB,IHC,ELISA |
| Application Info | This affinity-purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 140 kDa in size corresponding to ABCB1 protein by western blotting in the appropriate cell lysate or extract. |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human |
| Description | ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier. |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 262-277 of human ABCB1 protein. |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Recommended Dilutions | This affinity-purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 140 kDa in size corresponding to ABCB1 protein by western blotting in the appropriate cell lysate or extract. |
| Storage Buffer | PBS, pH 7.4 with 0.05% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human |
| Specificity | This affinity-purified antibody is directed against human ABCB1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross reactivity with ABCB1 protein from human, monkey, dog, mouse, and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known. |
| Purity | Affinity Purified |
| Guarantee | abm guarantees that all our Anti-ABCB1 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y052106 |
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