Anti-ATM (Ab-1981) Antibody
| Cat. No. | Y021147 |
| Name | Anti-ATM (Ab-1981) Antibody |
| Clone | Polyclonal |
| Category | Polyclonal Antibodies |
| Gene Name | ATM |
| Alias | TEL1, TELO1 |
| Application | WB,IP |
| Application Info |
WB: 1:500~1:1000 IF:1:100~1:200 |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human,Mouse |
| Description |
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010] |
| Immunogen | The antibody was produced against synthesized non-phosphopeptide derived from human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S). |
| Isotype | IgG |
| Concentration | 100ug/100ul |
| Recommended Dilutions |
WB: 1:500~1:1000 IF:1:100~1:200 |
| Storage Buffer | Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca<sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Condition |
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human,Mouse |
| Specificity | ATM (Ab-1981) Antibody detects endogenous levels of total ATM protein. |
| Purity | Affinity purified |
| Caution |
Not for diagnostic use. |
| Guarantee |
abm guarantees that all our Anti-ATM (Ab-1981) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y021147 |