Anti-BRCA1 (Ab-1524) Antibody
Cat. No.
Y021139
Unit
100 μg
Price
$319.00
| Cat. No. | Y021139 |
| Name | Anti-BRCA1 (Ab-1524) Antibody |
| Clone | Polyclonal |
| Category | Polyclonal Antibodies |
| Gene Name | BCR |
| Alias | D22S662, CML, PHL, ALL |
| Application | IP |
| Application Info | IF:1:100~1:200 |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human |
| Description | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen | The antibody was produced against synthesized non-phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1524 (Y-P-SP-Q-E). |
| Isotype | IgG |
| Concentration | 100ug/100ul |
| Recommended Dilutions | IF:1:100~1:200 |
| Storage Buffer | Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca<sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human |
| Specificity | BRCA1 (Ab-1524) Antibody detects endogenous levels of total BRCA1protein. |
| Purity | Affinity purified |
| Guarantee | abm guarantees that all our Anti-BRCA1 (Ab-1524) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y021139 |
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