Anti-C-mAhi-1 M5 Antibody
Cat. No.
Y030001
Unit
100 μg
Price
$232.00
| Cat. No. | Y030001 |
| Name | Anti-C-mAhi-1 M5 Antibody |
| Clone | Monoclonal |
| Category | Monoclonal Antibodies |
| Gene Name | AHI-1 |
| Application | WB,IHC,Other |
| Application Info | Application include Western blot analysis (1: 1000-2000 dilution), immunoprecipitation ( 1-2 ug / 200-800 ug protein) and immunostaining of cultured cells (1: 200-1000 dilution). |
| Raised In | Mouse |
| Clonality | Monoclonal |
| Reactivity | Mouse |
| Description | Abelson helper integration site-1 (Ahi-1) is a novel oncogene identified based on its common activation in v-abl and myc-induced murine lymphomas. The murine Ahi-1 gene encodes a unique protein with multiple SH3 binding sites, an SH3 domain and multiple WD40-repeat domains. The conserved human homolog (AHI-1) contains an additional coiled-coil domain in its N-terminal region. Both murine and human Ahi-1/AHI-1 genes encode at least three isoforms and thus this gene is also subject to alternative splicing in normal cells. Expression of Ahi-1/AHI-1 is regulated at multiple stages of hematopoiesis in a highly conserved fashion in mouse and humans. It is highly elevated in certain human lymphoma and leukemia cells, including those from patients with cutaneous T-cell lymphomas (CTCL), BCR-ABL chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). AHI-1 is also to be strongly expressed in embryonic hindbrain and forebrain, and AHI-1 may be required for both cerebellar and cortical development in humans. Defects in AHI-1 are the cause of Joubert syndrome, an autosomal recessive brain congenital malformation. |
| Immunogen | C-mAhi-1 M5 reacts with an epitope in the c-terminal region of mouse Ahi-1 protein. A recombinant mouse Ahi-1 GST fusion protein was used as immunogen. This antibody was purified from supernatant by affinity chromatography. |
| Isotype | IgG1 |
| Concentration | 100ug/100ul |
| Recommended Dilutions |
Application include Western blot analysis (1: 1000-2000 dilution), immunoprecipitation ( 1-2 ug / 200-800 ug protein) and immunostaining of cultured cells (1: 200-1000 dilution). |
| Storage Buffer | PBS, pH 7.4 with 0.02% sodium azide. |
| Storage Condition |
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Mouse |
| Specificity | Reacts with murine Ahi-1. |
| Purity | Affinity Purified |
| Caution |
For Research Use Only |
| Guarantee |
abm guarantees that all our Anti-C-mAhi-1 M5 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y030001 |
Print & Download Datasheet
Search CoA here
There are no Documents for this product yet!
There are no FAQs for this product yet!
- Chen, M et al. "Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex" J. Natl. Cancer Inst. 105:405-23 (2013). PubMed: 23446755.
- Liu, X et al. "Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors" Proteomics 12:2094-106 (2012). PubMed: 22623184.
This product has no review yet.
Browse Other Antibodies:
Select Rasied In:
Armenian hamster
(0)
Bovine
(0)
Chicken
(0)
Donkey
(0)
Goat
(0)
Golden Syrian Hamster
(0)
Guinea pig
(0)
Hamster
(0)
Horse
(0)
Human
(0)
Mouse
(0)
Other
(0)
Rabbit
(0)
Rat
(0)
Sheep
(0)
Select Reactivity:
Avian
(0)
Bombyx mori
(0)
Bovine
(0)
C. elegans
(0)
Chicken
(0)
CMV
(0)
Dog
(0)
Drosophila
(0)
E. coli
(0)
Fusarium sepsis
(0)
Hamster
(0)
HBV
(0)
Horse
(0)
Human
(0)
Llama
(0)
Locusta migratoria
(0)
Manduca
(0)
Mosquito
(0)
Mouse
(0)
Notapplicable
(0)
Other
(0)
Pig
(0)
Planaria
(0)
Porcine
(0)
Quail
(0)
Rat
(0)
Rodent
(0)
Sheep
(0)
Species independent
(0)
Spodoptera frugiperda
(0)
Xenopus
(0)
Zebrafish
(0)