Anti-Sortilin (Neurotensin receptor 3) Antibody
Cat. No.
Y051715
Unit
50μl
Price
$963.00
| Cat. No. | Y051715 |
| Name | Anti-Sortilin (Neurotensin receptor 3) Antibody |
| Clone | Polyclonal |
| Category | Polyclonal Antibodies |
| Gene Name | Sortilin |
| Application | WB,IHC |
| Application Info | For research purposes only, not for human use. |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human,Mouse,Rat |
| Description | Sortilin is a member of the Vps10p family named for a yeast gene that is involved in trafficking between the trans-golgi network and the vacuole. In mammals sortilin has been shown to play an important role in golgi to endosome and golgi to lysosome trafficking. Sortilin is also known as neurotensin receptor 3 (NTS3), one of the receptors for the peptide neurotransmitter neurotensin that exerts several biological functions ranging from the regulation of dopamine transmission and pain in the central nervous system to its functioning as a local hormone affecting the gastrointestinal tract. In addition, sortilin has been lately identified as a co-receptor of p75NTR for the binding of the proneurotrophins proNGF and proBDNF. Moreover, Sortilin expression was found to be essential for proNGF and proBDNF-induced neuronal cell death. Sortilin is a type I membrane protein with a large extracellular domain that includes 8 bacterial neuraminidase repeats (BNRs), a single transmembrane region and a short cytoplasmic tail. The protein is expressed in several tissues, most notably in brain, spinal chord, skeletal muscle and adipocytes. Paradoxically for its role as either a neurotensin receptor or a p75NTR co-receptor for proneurotrophins, about 90% of sortilin is retained in intracellular compartments with only about 10% reaching the cell surface. It has been speculated, that changes in the cellular environment may increase cell surface expression of sortilin. We have now developed a new anti-Sortilin antibody directed at the extracellular region of the human sortilin protein. The antibody will recognize human rat and mouse samples. |
| Immunogen | Peptide DKDTTRRIHVSTDQD(C) corresponding to residues 320-335 of human Sortilin (Accession Q99523). |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Recommended Dilutions | For research purposes only, not for human use. |
| Storage Buffer | PBS, pH 7.4 with 0.05% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human,Rat,Mouse |
| Purity | Affinity purified on immobilized antigen. |
| Guarantee | abm guarantees that all our Anti-Sortilin (Neurotensin receptor 3) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Y051715 |
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- Kimura, N et al. "Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function" Am J Pathol 180(2):550-61 (2012). DOI: 10.1016/j.ajpath.2011.10.037. PubMed: 22182700.
- Okabayashi, S et al. "LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation" Neuroreport 21:606-10 (2010). PubMed: 20461023.
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